From Emulate to TissUse: The Current State of Organ-on-Chip Technology Commercialization Read Full Post »
The Rise of Metabolomics: An Alternative to Toxicity Assessment and a Path to Animal Ethics Read Full Post »
Reducing Aggression in Group-Housed Male Mice: Practical Tips and Best Practices 🐭⚖️ Read Full Post »
Young Researchers from UK Universities Awarded Lush Prize for Groundbreaking Work in Non-Animal Testing Methods Read Full Post »
Bone-targeted delivery of bisphosphonate using nanoparticle carriers for the treatment of osteoporosis Read More »
Recent Advances in Biotechnology: TCR Cell Therapies, Enhanced mRNA Therapeutics, Plastic Bioremediation, and New CRISPR-Cas Innovations Read More »
Cutting-Edge Scientific Breakthroughs: Blood Stem Cells, Genetic Alphabet Expansion, CRISPR Therapies, and Advances in Neurotechnology Read More »
How Far Has the ‘Organoid Matrix’ Come in Erasing the Boundary Between Reality and Virtual World? Read More »
Breakthroughs in Human Embryonic Development Research: The Dawn of Human Cloning Reality? Read More »
🎀Revolutionary Breast Cancer Treatment: New “Breast Cancer-on-Chip” Model for CAR-T Cell Efficacy and Safety Testing Read More »
Advancements in Brain Research: Unveiling the Blood-Brain Barrier Through Organoid Technology Read More »
Groundbreaking Research on Human Liver Organoids Offers Hope for Early Detection of Drug-Induced Liver Injury Read More »
International Research Team Achieves First-reported, Complete Vascularization of Organoids on Microfluidic Chip Read More »
ASU Researcher’s Microscale Tech is Chipping Away at Cancer, Organ Failure and Neurological Disease Read More »
Young Researchers from UK Universities Awarded Lush Prize for Groundbreaking Work in Non-Animal Testing Methods Read More »
A Human Brain Microphysiological System Derived from Induced Pluripotent Stem Cells to Study Neurological Diseases and Toxicity Read More »
Prolonged culturing of colonic epithelial organoids derived from healthy individuals and ulcerative colitis patients results in the decrease of LINE-1 methylation level Read More »
A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens Read More »
USC Stem Cell scientists develop a game-changing organoid model to study human cerebellar development and disease Read More »
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids Read More »
Key Biotech and Healthcare Updates: FDA Approvals, Industry Leaders, and Global Market Growth Read More »
Key Healthcare and Biotech Developments: FDA Approvals, Investment Insights, and Global Expansions Read More »
Recent Pharma and Biotech Milestones: FDA Approvals, Major Acquisitions, and Record-Setting IPOs Read More »
Biotech Funding and Acquisitions: Gene Therapy, Xenotransplantation, and AI-Driven Advances Read More »
🛠️Engineered Matrices Reveal Stiffness-Mediated Chemoresistance in Patient-Derived Pancreatic Cancer Organoids Read More »
🔬Organoid-Based Assessment of Metal-Organic Framework (MOF) Nanomedicines for Ex Vivo Cancer Therapy Read More »
GenScript Biotech Corporation Launches FLASH Gene Service: The Fastest and Most Affordable Gene Synthesis Solution on the Market Read More »
❤️🩹Single-Cell Functional Profiling Using Nanovial Technology Unveils the Therapeutic Potential of Extracellular Vesicles Read More »
OrganoIDNet: A Deep Learning Tool for Identification of Therapeutic Effects in PDAC Organoid-PBMC Co-cultures from Time-Resolved Imaging Data Read More »
FinalSpark Launches the First Remote Research Platform Using Human Neurons for Biocomputing Read More »
ASU Researcher’s Microscale Tech is Chipping Away at Cancer, Organ Failure and Neurological Disease Read More »
Young Researchers from UK Universities Awarded Lush Prize for Groundbreaking Work in Non-Animal Testing Methods Read More »
🫁NF-κB Inhibitor Alpha Controls SARS-CoV-2 Infection in ACE2-Overexpressing Human Airway Organoids Read More »
💾An Ultrathin Membrane Mediates Tissue-Specific Morphogenesis and Barrier Function in a Human Kidney Chip Read More »
Characterization of Patient-Derived Intestinal Organoids for Modelling Fibrosis in Inflammatory Bowel Disease Read More »
Azoxymethane-Induced Carcinogenesis-Like Model of Mouse Intestine and Mouse Embryonic Stem Cell-Derived Intestinal Organoids Read More »
Modeling Blood-Brain Barrier Formation and Cerebral Cavernous Malformations in Human PSC-Derived Organoids Read More »
Efficient Hepatocyte Differentiation of Primary Human Hepatocyte-Derived Organoids Using Three Dimensional Nanofibers (HYDROX) and Their Possible Application in Hepatotoxicity Research Read More »
Heterozygous RB1 Mutation Enhanced ATP Production in Human iPSC-Derived Retinal Organoids Read More »
Synergistic Hyperactivation of Both mTORC1 and mTORC2 Underlies the Neural Abnormalities of PTEN-deficient Human Neurons and Cortical Organoids Read More »
Hyaluronan Improves Photoreceptor Differentiation and Maturation in Human Retinal Organoids Read More »
High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in a Translational Canine Intestinal Organoid Model Read More »
Organoids as Advanced Model in Cancer Biology: The Drug Screening and Clinical Applications Read More »
Pioneering Technologies Transforming Drug Discovery: From Preclinical Assessments to Clinical Trials Read More »
Vitamin D Opposes Multilineage Cell Differentiation Induced by Notch Inhibition and BMP4 Pathway Activation in Human Colon Organoids Read More »
Endogenous Mutant Huntingtin Alters the Corticogenesis via Lowering Golgi Recruiting ARF1 in Cortical Organoid Read More »
Claudin-7 Is Essential for the Maintenance of Colonic Stem Cell Homoeostasis via the Modulation of Wnt/Notch Signaling Read More »
FGF7 Enhances the Expression of ACE2 in Human Islet Organoids Aggravating SARS-CoV-2 Infection Read More »
Establishment, Characterization, and Biobanking of 36 Pancreatic Cancer Organoids: Prediction of Metastasis in Resectable Pancreatic Cancer Read More »
A Pancreatic Cancer Organoid-in-Matrix Platform Shows Distinct Sensitivities to T Cell Killing Read More »
A Patient-specific Lung Cancer Assembloid Model with Heterogeneous Tumor Microenvironments Read More »
Quantifying Y Chromosome Loss in Primary and Metastatic Prostate Cancer by Chromosome Painting Read More »
Identification of Genes that Promote PI3K Pathway Activation and Prostate Tumour Formation Read More »
In Utero and Postnatal Ivacaftor/Lumacaftor Therapy Rescues Multiorgan Disease in CFTR-F508del Ferrets Read More »
SF3B3-regulated mTOR Alternative Splicing Promotes Colorectal Cancer Progression and Metastasis Read More »
Modeling Acute Myocardial Infarction and Cardiac Fibrosis Using Human Induced Pluripotent Stem Cell-Derived Multi-Cellular Heart Organoids Read More »
Survival and Functional Integration of Human Embryonic Stem Cell–Derived Retinal Organoids after Shipping and Transplantation into Retinal Degeneration Rats Read More »
Blood Vessel Organoids Generated by Base Editing and Harboring Single Nucleotide Variation in Notch3 Effectively Recapitulate CADASIL-Related Pathogenesis Read More »
High-Dose Short-Term Osimertinib Treatment Is Effective in Patient-Derived Metastatic Colorectal Cancer Organoids Read More »
International Research Team Achieves First-reported, Complete Vascularization of Organoids on Microfluidic Chip Read More »
Establishment of Patient-derived Organoids for Guiding Personalized Therapies in Breast Cancer Patients Read More »
Parechovirus Infection in Human Brain Organoids: Host Innate Inflammatory Response and not Neuro-infectivity Correlates to Neurologic Disease Read More »
ASU Researcher’s Microscale Tech is Chipping Away at Cancer, Organ Failure and Neurological Disease Read More »
Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine Read More »
cDC2 Plasticity and Acquisition of a DC3-Like Phenotype Mediated by IL-6 and PGE2 in a Patient-Derived Colorectal Cancer Organoids Model Read More »
MSCs Alleviate LPS-Induced Acute Lung Injury by Inhibiting the Proinflammatory Function of Macrophages in Mouse Lung Organoid-Macrophage Model Read More »
Microglial Over-Pruning of Synapses during Development in Autism-Associated SCN2A-Deficient Mice and Human Cerebral Organoids Read More »
Efficient Generation of Skin Organoids from Pluripotent Cells via Defined Extracellular Matrix Cues and Morphogen Gradients in a Spindle-Shaped Microfluidic Device Read More »
Patient Derived Tumoroids of High Grade Neuroendocrine Neoplasms for More Personalized Therapies Read More »
Single-Cell Guided Prenatal Derivation of Primary Fetal Epithelial Organoids from Human Amniotic and Tracheal Fluids Read More »
Neuromuscular Organoids Model Spinal Neuromuscular Pathologies in C9orf72 Amyotrophic Lateral Sclerosis Read More »
Integration of Kupffer Cells into Human iPSC-Derived Liver Organoids for Modeling Liver Dysfunction in Sepsis Read More »
Preclinical Efficacy and Safety of Encapsulated Proliferating Human Hepatocyte Organoids in Treating Liver Failure Read More »
Deciphering Fibroblast-induced Drug Resistance in Non-small Cell Lung Carcinoma Through Patient-derived Organoids in Agarose Microwells Read More »
A Functional Personalised Oncology Approach Against Metastatic Colorectal Cancer in Matched Patient-derived Organoids Read More »
A Human Brain Microphysiological System Derived from Induced Pluripotent Stem Cells to Study Neurological Diseases and Toxicity Read More »
Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations Read More »
Organoid Forming Potential as Complementary Parameter for Accurate Evaluation of Breast Cancer Neoadjuvant Therapeutic Efficacy Read More »
Effective AAV-Mediated Gene Replacement Therapy in Retinal Organoids Modelling AIPL1-Associated LCA4 Read More »
Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms Read More »
Mitochondrial network physiology disruption during SARS-CoV-2 infection in human lung organoids Read More »
Rapid Generation of hPSC-Derived High Endothelial Venule Organoids with In Vivo Ectopic Lymphoid Tissue Capabilities Read More »
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development Read More »
Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions Read More »
Mapping the developmental potential of mouse inner ear organoids at single-cell resolution Read More »
Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids Read More »
Urine-derived bladder cancer organoids (urinoids) as a tool for cancer longitudinal response monitoring and therapy adaptation Read More »
Prolonged culturing of colonic epithelial organoids derived from healthy individuals and ulcerative colitis patients results in the decrease of LINE-1 methylation level Read More »
A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens Read More »
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration Read More »
USC Stem Cell scientists develop a game-changing organoid model to study human cerebellar development and disease Read More »
Novel model of cortical–meningeal organoid co-culture system improves human cortical brain organoid cytoarchitecture Read More »
Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients Read More »
One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids Read More »
